Skip to Main Content
It looks like you're using Internet Explorer 11 or older. This website works best with modern browsers such as the latest versions of Chrome, Firefox, Safari, and Edge. If you continue with this browser, you may see unexpected results.

Evidence-Based Practice: SEARCH EBP Tools & Pyramid

This guide is designed to assist health care professionals to become effective and efficient users of the medical and nursing literature.

Best Evidence Pyramid and Clinical Resources

Evidence-Based Clinical Practice Resources

Evidence-Based Medicine is the integration of best research evidence with clinical expertise and patient values. (Sackett DL, Straus SE, Richardson WS, et al. Evidence-based medicine: how to practice and teach EBM. 2nd ed. Edinburgh: Churchill Livingstone, 2000.)

Image from here




Evidence at the TOP  of the pyramid is easier to find and apply.

Items at the BOTTOM of the pyramid are closer to raw data and require more interpretation / appraisal.


TRIP (Turning Research into Practice) Database

Simultaneously searches evidence-based sources of systematic reviews, practice guidelines, and critically appraised topics and articles--including most of those listed above and many more.  Also searches MEDLINE's Clinical Queries, medical image databases, e-textbooks, and patient information leaflets. 

Filtered Resources   appraise the quality of studies and often make recommendations for practice.


Systematic Reviews / Meta-Analyses


The Cochrane Database of Systematic Reviews

  • Gold Standard for high-quality systematic reviews
  • Abstracts for Cochrane Reviews are indexed in PubMed with links to the full-text
  • Cochrane Reviews include completed reviews and protocols (reviews in progress)
  • Consists of detailed, structured topic reviews of hundreds of articles. Teams of experts complete comprehensive literature reviews, evaluate the literature, and present summaries of the findings of the best studies.
  • Published by the International Cochrane Collaboration.

  What is the Cochrane Library?        Sample Cochrane Library Abstract


The Database of Abstracts of Reviews of Effect (DARE) 

  • Structured abstracts of systematic reviews from a variety of medical journals
  • Structured Abstracts (NOT full-text articles)
  • DARE is produced by the National Health Service Centre for Reviews and Dissemination (NHS CRD) at the University of York, England.
  • Complements the Cochrane Reviews by offering a selection of quality assessed reviews in those subjects where there is currently no Cochrane Review.
  • Brief critical appraisals of previously published reviews of the effects of health care
  • Topics include : diagnosis, prevention, rehabilitation, screening, and treatment.
  • DARE is not indexed in PubMed, but the original research articles may be listed.


‚ÄčPubMed Clinical Queries - Systematic Reviews

  • Identifies systematic reviews and other similar types of studies found in biomedical journals included in the PubMed database.  PubMed gathers together a much larger collection than other evidence-based practice resources
  • No evaluation of comparative quality of different reviews on a topic
  • Abstracts supplied by authors / journals.  No separate evaluation of quality of research
  • These articles * may * require critical appraisal

 In PubMed: Click on Clinical Queries at the bottom of the screen; Select "Find Systematic Reviews" and enter your search query.

  • To find a meta-analysis, search your topic in PubMed.  On the left side of the results screen, open the Article Type Filter for more options  >  Choose Meta-Analysis.  Click to apply this filter to your results. 
  • Use  the Ministry Library PubMed link to access even more full-text.

Systematic Reviews in  Ovid MEDLINE :

  • Enter your search query;
  • Click on the Limits icon
  • Select "Systematic Reviews" under "Subject Subsets."


Critically-Appraised Topics (CATs)   evaluate and synthesize multiple research studies. 



DynaMed (Ebsco)

Nursing Reference Center Plus (Ebsco)

  •  Includes Evidence-based Care Sheets


ECRI Guidelines Trust

  • Replaces The National Guideline Clearinghouse after funding ceased as of July 2018, however.  
  • A comprehensive database of evidence-based and trustworthy clinical practice guidelines and related documents
  • Requires FREE registration.
  • Browse guideline briefs of expertly vetted guidelines.
    • Each Brief includes ECRI's new TRUST Scorecard which evaluates how a guideline stacks up against the Institute of Medicine Standards for trustworthiness.
  • Note: Guideline evidence varies from expert opinion to high levels of evidence.


Natural Medicines  [Legacy Ministry / Affinity access only]

  • High quality evidence-based info about complementary and alternative medicine,
  • Herbal medicines, dietary supplements, and integrative therapies.
  • Evidence Grades reflect the level of available scientific evidence for or against the use of each therapy for a specific medical condition.

PDQ (Physician Data Query)

  • From the National Cancer Institute (NCI)
  • Treatment summaries for adults and children, written for physicians and patients. 
  • Summaries are specific to cancer type and site and are updated frequently. 
  • Prevention and palliative care summaries are also available.
  • Links to the literature are provided. 


Critically-Appraised Individual Articles  evaluate and synopsize individual research studies. 

CATs are critical summaries of a research article.  They are concise, standardized, and provide an appraisal of the research.

If a CAT already exists for an article, it can be read quickly and the clinical bottom line can be put to use as the clinician sees fit.  If a CAT does not exist, the CAT format provides a template to appraise the article of interest.


"Evidence-Based" Journal series   (e.g., Evidence-Based Medicine, Evidence-Based Mental Health, Evidence-Based Nursing) Primary research articles within the discipline are selected for quality and clinical relevance. A structured abstract and expert commentary are provided for each study.

         Evidence-based Medicine       Evidence-based Mental Health     Evidence-Based Nursing

Check the Library's A-Z Journals List  for additional Evidence-based ... journal subscriptions.

Unfiltered Resources

Evidence is not always available via filtered resources.  Searching the primary literature may be required.  It is possible to use specific search strategies in Medline and other databases to achieve the highest possible level of evidence.


PubMed Clinical Queries - Clinical Study Categories

To limit your PubMed search to the best evidence-producing studies: Click on "Clinical Queries" (towards the bottom of the screen).   For comprehensive searches, use the full PubMed.

  • Clinical Queries use preconfigured search strategies to pull up research-based citations on clinical topics in the areas of : therapy, diagnosis, etiology, diagnosis, or prognosis
  • Broad Scope = More Sensitive Results (i.e., include most relevant articles but probably including some less relevant ones
  • Narrow Scope = More Specific Results (i.e., including mostly relevant articles but probably omit a few)
  • Note : Filtered by publication type, but not quality
  • Use Filters / Limits to seach by specific publicaton types (RCT, case report, case series, review, etc.)
  • Search one publication at a time.

Ovid Medline

  • To limit your Ovid MEDLINE search to the best evidence-producing studies, use Clinical Queries (See PubMed above ).  Run your search, then click on the Additional Limits icon.Clinical Queries in Ovid Medline includes : reviews, therapy, diagnosis, prognosis, causation-etiology, economics, costs, and qualitative
  • Set the scope of your search with specificity (narrow) or sensitivity (broad) options, in addition to "best balance" between the two.


  • Cumulative Index to Nursing and Allied Health Literature
  • To limit your CINAHL search to the best evidence-producing studies:
    • Click on the "Limits" icon to use Clinical Queries as above
    • Or limit to Research
    • Or limit to Evidence-based Practice.  
      • This is a journal subset applied to articles from evidence based practice journals (including Cochrane), as well as articles about evidence based practice, research articles (including systematic reviews, clinical trials, meta analyses, qualitative studies), commentaries on research studies (applying practice to research), case studies if they meet the criteria of the use of research and/or evidence based practice terms.


Google Scholar

  • If using at an Affinity/Ministry computer, this url will tap into Ministry Library Services' full-text offerings.
  • Searches the full-text of scholarly journals, but requires a carefully-crafted search strategy to get useful results.
  • These articles will require evaluation and appraisal

Background Information/Expert Opinion

Note: Evidence in these resources may vary from expert opinion to high levels of evidence.


  • Contains eMedicine's high-quality medical topic reviews
  • Peer-reviewed clinical medicine.  eMedicine's professional content undergoes multiple levels of physician peer review.
  • Physician authors and editors contribute to the eMedicine Clinical Knowledge Base, which contains articles on 7,0000 diseases and disorders.  The evidence-based content provides the latest practice guidelines in 62 medical specialties.
  • Requires FREE personal login to access clinical content.    
    • Or use the Generic Username : affinity1 Password : library

Harrison's Online (via AccessMedicine)

  • Searchable and continually updated version of Harrison's Principles of Internal Medicine.


Clinical Overviews & FirstConsult (part of ClinicalKey)

  • High quality medical topic summaries related to patient care.
  • Grades the available evidence.
  • Part of Clinical Key
  • Point -of-care tool



  • Full-text medical books. Includes Harrison's Online, Current Medical Diagnosis and Treatment, William's Obstetrics, Hurst's the Heart and many more ...
  • Also includes drug info, differential diagnosis, and guidelines.


Lippincott Nursing Procedures (via R2)

2019 edition.


Lippincott Manual of Nursing Practice (via R2)

2019 edition.


EBM Pyramid and EBM Page Generator. (c) Copyright 2006-2011. Trustees of Dartmouth College and Yale University. All Rights Reserved.
Produced by Jan Glover, David Izzo, Karen Odato and Lei Wang.

Updated  23 December 2020.

Contact Your Librarian : MM

Need Assistance? We are happy to help! Please contact Your Librarian :


Michele Matucheski, MLIS, AHIP
Medical Librarian
(920) 223-0340


Ascension Wisconsin Associate Intranet CSM Library Intranet MHC Library Intranet WFHC Library Intranet What's New with Ascension Wisconsin Library Services Blog